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An Integrated Approach to Testing and Assessment of Chemical Mixtures in the Environment: The Advent of Adverse Outcome Pathway Footprinting (ASCCT)
Citation:
Lambert, J. An Integrated Approach to Testing and Assessment of Chemical Mixtures in the Environment: The Advent of Adverse Outcome Pathway Footprinting (ASCCT). American Society for Cellular and Computational Toxicology (ASCCT) annual meeting, Gaithersburg, MD, September 25 - 26, 2019. https://doi.org/10.23645/epacomptox.11342225
Impact/Purpose:
Abstract and presentation for The American Society for Cellular and Computational Toxicology (ASCCT) annual meeting held September 2019. The topic will be 'Computational Toxicology: Peeking into the Clouds while Keeping our Feet on Solid Ground'. This presentation will provide an overview of AOP footprinting and how it compliments an integrated approach to testing and assessment (IATA) of environmental chemical mixtures.
Description:
Human health assessment of environmental chemical mixtures has perpetually been limited by the availability of adverse health outcome data to inform hazard and dose-response assessment. That is, traditional mixtures assessment theory and practice, such as dose additivity, places emphasis on the comparison of toxicological similarity at the level of phenotypic effect or endpoint. The virtual absence of whole mixtures data at environmentally relevant exposure levels or proportions, and, limited availability of traditional toxicity bioassay information for individual mixture component chemicals, has resulted in very few mixtures assessments that support some type of regulatory decision-making. With the advent of New Approach Methods toxicity testing and data, such as adverse outcome pathway (AOP), opportunities to evaluate hazards associated with exposure to ‘data-poor’ mixture chemicals have advanced significantly. Potential health impact(s) of mixture chemicals may be informed using an integrated read-across approach that includes AOP ‘footprinting’ when adverse health outcome data derived from traditional bioassays are lacking. In brief, AOP footprinting makes use of key event data to inform qualitative and quantitative relationships between mixture components. This presentation will provide an overview of AOP footprinting and how it compliments an integrated approach to testing and assessment (IATA) of environmental chemical mixtures. The views expressed in this abstract are those of the author and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency.
URLs/Downloads:
DOI: An Integrated Approach to Testing and Assessment of Chemical Mixtures in the Environment: The Advent of Adverse Outcome Pathway Footprinting (ASCCT)
LAMBERT_ASCCT 2019.PDF (PDF, NA pp, 2212.346 KB, about PDF)